Immune Repertoire Sequencing Service

NGS-based BCR, TCR Sequencing, Ultrasensitive MRD Monitoring


Ultra-sensitive Monitoring of B-cell, T-cell Clonality

Immune Repertoire often represents an individual’s current immunological status, whether healthy, vaccinated, diseased or infected. At Celemics, we offer the most advanced Immune Repertoire profiling service to provide you with a comprehensive analysis of B-cell and T-cell clonality.

Our cutting-edge high-throughput NGS analysis enables to fully profile immune repertoire with accuracy and precision. With Celemics’ Immune Repertoire sequencing service, you’ll receive an ultra-sensitive, accurate, and optimized profiling of IgH, IgK, TRB, and TRG with complete V(D)J variable regions. Trust Celemics to provide you with the most reliable and effective data acquisition, integration, and interpretation available.


Features & Benefits

Molecular Barcode Technology for Quantitative Clonality Analysis with Ultra-high Sensitivity and Accuracy

Our advanced NGS-based analysis provides complex antibody libraries with millions of sequences, all in a single experiment. At Celemics, we developed proprietary molecular barcode technology to analyze the immunoglobulin and T-cell receptor repertoire, providing a comprehensive BCR/TCR analysis for each clone. With our molecular barcodes, we can identify individual antibody clones within a library and identify major and minor clones, giving you a complete picture of your sample and helping you make informed decisions for your research.

CDR3 sorting results

– Discovery of candidate antibodies from actively immunized chickens

CDR3 ID CDR3 AA p_pre-immune p_immune p_1st_boost p_2nd_boost p_tissue p_BM_2nd
CDR3sample_1 GSRDSSASTI 2433 773 31 0 2 461
CDR3sample_2 GSYDSSYVGI 1756 1444 2269 895 1058 789
CDR3sample_3 GSIDSSYVGI 1019 402 876 938 541 346
CDR3sample_4 ANFDSSSGAGI 46 25 338 483 1707 345
CDR3sample_5 GGYDSSAGI 231 268 934 207 966 7770
CDR3sample_6 GSFDSSTYAGI 3678 1034 425 290 547 431
CDR3sample_7 GSRDSSASTI 2433 773 31 0 2 461
CDR3sample_8 GSRDSSYVGI 6427 6370 10151 5756 10089 2680
CDR3sample_9 GGYDGSTYVGI 279 211 2047 178 271 88
CDR3sample_10 GSRDSNYVGI 407 567 974 749 868 224
CDR3sample_11 GSSSGTGI 1563 2580 899 1999 114 24702
CDR3sample_12 GSYDSSAGI 1195 875 1342 743 746 288
CDR3sample_13 GSRDSTYVGI 461 795 1355 998 983 136
CDR3sample_14 GGYDSSTDAGI 1167 1129 1353 1617 892 405

Sequence abundance clustering result

– Discovery of candidate antibodies from actively immunized chickens

Sequence abundance clustering result





CDR3 similarity analysis

– Discovery of novel drug candidates with antibody analysis from respiratory infection patient samples

Network Analysis Between Antibody Sequences

– Discovery of novel drug candidates with antibody analysis from respiratory infection patient samples

Tracking of Clonal Frequencies for Each Sample

Monoclonality can be analyzed by sequencing the rearrangement pattern of lymphocyte receptor DNA in the bone marrow or peripheral blood of patients with lymphoproliferative disorders. The unique rearrangement DNA sequences of all lymphocytes in the specimen are analyzed by sequencing, and are ranked based on the proportion of each unique sequence. Unique rearrangement DNA is considered a monoclonal sequence and is used as a target for minimal residual disease (MRD) monitoring tests.

At Celemics, we take care to minimize the omission of unique sequences, ensuring that you get the most complete picture of your sample and the best results possible.

Provision of Bioinformatics Service of Various Analysis Options for Immune System Studies

Celemics provides various bioinformatic services including clonal read count, clonal read frequency, Post Translational Modification (PTM) analysis, sequence-based antibody clustering, and network analysis. Our proprietary bioinformatics analysis pipeline provides visible and easy-to-read results for customer’s specimen.


General workflow of Immune Repertoire Profiling service

General workflow of Immune Repertoire Profiling service

Patient or Subject



Data integration
& analysis

Data integration


General workflow of Immune Repertoire Profiling service


Sample type Total RNA from B-cell or/and T--cell, DNA from B-cell or/and T-cell, DNA/RNA Amplicons
Target size 100 ng/µl
Amount 1 µg
Turnaround time Within 4-6 business weeks from sample collection
Temperature RT for storage and shipment

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Technical Resources

[Product Overview] Immune Repertoire profiling Service

[Product Overview] Celemics Target Enrichment Panel Overview

[Catalogue] Celemics Products & Service Catalogue_All Products & Service