Each sequencing platform has its own advantages and limitations depending on its sequencing chemistry and operating principles. For this reason, many research environments operate multiple platforms depending on their analysis goals.

In such environments, selecting a kit provider with broad platform compatibility can significantly improve operational efficiency.

To achieve optimal performance on each platform, it is generally advantageous to use kits designed with the platform’s native adapter structure. This approach avoids additional PCR or conversion steps, thereby minimizing amplification bias and potential sample loss during purification.

On the other hand, for laboratories already familiar with Illumina-based workflows, using conversion kits can be an effective strategy when adopting additional sequencing platforms. Existing protocols can be maintained, which is particularly beneficial in laboratories using automated systems where workflow changes should be minimized.

In this approach, experiments are performed using the same Illumina-based workflow, and only the final conversion step is applied to adapt the library to the target sequencing platform. This also improves reagent standardization and inventory management. The diversification of sequencing platforms expands available options but also increases operational complexity. Celemics supports flexible multi-platform operation by providing both platform-specific adapter kits and library conversion kits.