Global Flu Outbreak and the Need for Influenza Sequencing
Influenza outbreaks are rapidly spreading worldwide. Both the United States and South Korea report Influenza A(H3N2) as the dominant subtype, drawing increased attention from clinicians and researchers. In particular, the H3N2 subclade K variant is being detected at high frequencies in both regions, underscoring the need for genome-level variant analysis and continuous surveillance. In this context of rapidly evolving influenza strains, sequence-based analysis—beyond simple positive/negative diagnostic results—plays a critical role in public health response and research.
Beyond Diagnosis: Why Influenza Virus Sequencing Is Essential
While molecular diagnostics such as RT-PCR are effective for detection, they have limitations in identifying circulating subtypes, mutation patterns, and sequence-level differences. Sequencing-based analysis enables the characterization of circulating strains and supports research and surveillance through the generation of reliable genomic data.
Influenza Virus Sequencing: Approaches Depending on Research Objectives
Influenza virus sequencing strategies vary depending on sample condition and analytical goals.
Accordingly, Celemics offers two influenza-specific sequencing solutions:
- Target enrichment-based WGS approach
- Amplicon-based WGS approach
Influenza WGS Target Enrichment Panel
The Influenza WGS Target Enrichment Panel is a target capture-based WGS solution designed for the simultaneous analysis of Influenza A and B viruses.
- Broad coverage of diverse Influenza A and B subtypes
- Probe-based target enrichment technology
- Suitable for damaged clinical samples and environmental samples (e.g., wastewater, avian droppings)
Recommended for applications requiring stable sequencing performance from variable-quality samples or environmental sources.
Influenza WGS Target Enrichment Panel – Data Example
Uniform coverage was observed across all eight genome segments, including key regions such as HA and NA.
Influenza WGS Amplification Solution
The Influenza WGS Amplification Solution is designed to efficiently perform influenza virus whole-genome sequencing using a primer-based amplicon approach.
- Dedicated WGS designs for Influenza A or Influenza B
- Fast and simplified workflow
- Suitable for high-throughput sample processing
Recommended for rapid WGS analysis of pre-typed Influenza A or B samples, particularly in large-scale screening settings.
Influenza WGS Amplification Solution – Data Example
Uniform coverage was observed across all eight genome segments, including key regions such as HA and NA.
Celemics provides influenza-specific WGS solutions that combine target enrichment and amplicon-based approaches to support accurate variant analysis and genomic monitoring.These flexible workflows enable reliable whole-genome sequencing across diverse sample types and research objectives.
Explore Celemics’ influenza WGS solutions and discover how target enrichment and amplicon-based approaches support accurate variant analysis and genomic monitoring.
👉 https://www.celemics.com/products/ready-to-use-ngs-panel/ngs-pathogen-analysis-kit/
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