CancerScreen CUP
Explore the Unknown Primary Cancer with Celemics Exclusive Technology
Overview
CancerScreen CUP
Methylation sequencing can identify the locations and levels of methylated DNA in a genome-wide or targeted manner for various applications of epigenetic research. Celemics’ solution for DNA methylation sequencing can provide more comprehensive and detailed patterns of either genome-wide or specific target region of your choice. Also, Celemics targeted methylation sequencing can provide solutions for the study of Cancer of Unknown Primary (CUP) to classify and originate the metastatic tumors, leading to the precision-driven therapeutic interventions.
Exclusive Probe Designed for
Methylation Sequencing
With the probes specifically designed for methylation sequencing, Celemics performs comparison analysis of the sequences before and after C-T conversion, enabling accurate detection of methylation sites.
Targeted Methylation Sequencing Workflow
Celemics provides and support easy-to-follow protocol for methylation sequencing.
* C/T Conversion Kit not provided; Celemics can provide optimization services with any C-T conversion kit of choice.
Celemics Products
Third Party Products & Software
DNA
Samples
Library
Preparation
C/T
Conversion
Target
Enrichment
Sequencing
Bioinformatics
Analysis
Analysis
Results
Figure 1. Targeted methylation sequencing workflow. Celemics provides and support easy-to-follow protocol for methylation sequencing.
* C/T Conversion Kit not provided; Celemics can provide optimization services with any bisulfite conversion kit of choice.
Process for Exclusive Celemics’ methyl-seq Probe Design
Celemics introduces exclusive set of probes specifically designed for methylation sequencing, considering the sequence alteration by C-T conversion.
C/T Conversion Kit
(Methylated)
(Unmethylated)
PCR
"C/T Probe"
(Methylated)
(Unmethylated)
PCR
"G/A Probe"
Figure 2. Process for exclusive Celemics’ methyl-seq probe design. Celemics introduces exclusive set of probes specifically designed
for methylation sequencing, considering the sequence alteration by bisulfite conversion.
Targeted Methylation Sequencing for
CUP Classification
Celemics Customized Targeted Methylation Sequencing Panel Solution offers proprietary probe design and a specialized workflow for detecting and classifying the Cancer of Unknown Primary (CUP). The performance data below represents analyses of 14 samples, which comprised cell lines from 5 different cancer types, demonstrating its compatibility and operability for successfully categorizing and identifying the origin of the tumors.
31 Target Cancer Types of Celemics CancerScreen CUP
| ACC | BLCA | BRCA | CESC | CHOL | COAD | DLBC |
| ESCA | GBM | HNSC | KICH | KIRC | KIRP | LGG |
| LIHC | LUAD | LUSC | MESO | PAAD | PCPG | PRAD |
| READ | SARC | SKCM | STAD | TGCT | THCA | THYM |
| UCEC | UCS | UVM |
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