Comprehensive Respiratory Virus Panel

Superior Success Rate even with Low Amounts of Clinical Sample

Overview

Respiratory Viral WGS with Celemics Comprehensive Respiratory Virus Panel

Detection panel for the accurate sequencing and identification of prominent whole viral genomes, including SARS-CoV-2 mutations and variants (ex. Omicron, Delta).


Viruses are continuously evolving in ways that make them increasingly infectious and difficult to cure. Thus, the discovery of specific disease-causing viral strains and research into their ability to spread within individuals in a given population have become a paramount public health issue. The Celemics Comprehensive Respiratory Virus Panel (CRV Panel) was developed to detect and sequence respiratory disease-causing viruses in humans using the NCBI RefSeq database as its foundation. It allows for the Whole Genome Sequencing of SARS-CoV-2 and all its relevant mutations and variants, and enables simultaneous testing of 9 different virus types and its 39 strains of clinically significant and prevalent respiratory viruses.

respiratory-virus
Features & Benefits

Provision of 9 different, 39 different strains of viruses, including SARS-CoV-2 Whole genome sequence

The comprehensive respiratory panel is designed to provide whole genome sequences for 39 different strains of respiratory viruses, including SARS-CoV-2 and all related mutations as well as opportunities for other novel variant detection.


With Celemics’ branded technologies, we provide exceptional success rate of respiratory virus detection and whole viral genome sequencing.

Exceptional Variant Detection Success Rate and WGS even in Low- viral Load Clinical Sample

The CRV panel ensures to provide superior WGS success rate and pathogen classification even with poor quality specimen, such as low viral load clinical specimen or poor quality environment-originated samples. Using Celemics’ CRV panel, you will witness the robust pathogen detection accuracy with significantly reduced gap formation compared to other competitor products.

Excellent and high coverage from clinical samples using CRV Panel

The performance test results from clinical samples show excellent Whole Genome coverage.

Sample Type Coverage (1X) Coverage (10X) Coverage (100X)
Clinical specimen 99.95% 99.87% 98.95%

Mutation Frequency and Genomic Structure of SARS-CoV-2 Variants

Coverage of Wide Range of Respiratory Pathogens

Celemics’ CRV panel is designed to assess wide range of respiratory pathogens. The panel will allow whole genome sequencing of 39 strains for 9 different virus types (SARS-CoV-2 solo analysis is also possible); includes all types of respiratory virus that are commonly assessed by medical institutions around the globe. Using the panel, you can evaluate double pandemic or co-infection in a single assay.

Easy assessment of numerous respiratory pathogens

※ Celemics provides stand-alone SW for BI analysis, allowing customers to access detailed data analysis information and ensuring the security of client sequence information.

SARS-CoV-2 Genome Coverage

Easy assessment of numerous respiratory pathogens

1X Coverage

Easy assessment of numerous respiratory pathogens

Virus Distribution / Virus Depth

Other Features

Other features image

User-friendly Celemics
Virus Verifier

Celemics’ own stand-alone Bioinformatics SW for easy data analysis

Other features image

Simple Workflow with
All-inclusive Kits

Shorter hybridization time with Celemics ‘Enhancer’ Solution


Ready to use double-stranded cDNA synthesis kit

Other features image

Flexible Integration on
Various Sequencing Platform

Compatible with various sequencer; made possible with Celemics’ chemistry optimization and blocker technology

Workflow

Inclusive preparation kit provided directly from Celemics

Portions of the procedure covered through the Complete Kit are highlighted in Red Competitors: 16 hours (Target Enrichment step, Hybridization Capture)

01

RNA extraction

02

NGS Iibrary Preparation

cDNA synthesis, NGS Prep.

~5 hours

03

Target enrichment

Hybridization capture

~ 4 hours

04

Sequencing

All Illumina and Thermo Fisher Scientific Sequencers

Depending on read length

05

Data analysis

Virus Data Report

~ 3 hours

01

RNA extraction

02

NGS Iibrary Preparation

cDNA synthesis, NGS Prep.

~5 hours

03

Target enrichment

Hybridization capture

~ 4 hours

04

Sequencing

All Illumina and Thermo Fisher Scientific Sequencers

Depending on read length

05

Data analysis

Virus Data Report

~ 3 hours

Specification

“CRV Panel Specification”

Target Virus 9 types / 39 virus strains, including SARS-CoV-2
Target Size 706 Kb
Mutation Analysis Variant detection, Viral mutation (SNV, Indel) from generated Whole Genome Sequence
Sample Type URT, NP/OP, etc.
Platform All Illumina and Thermo Fisher Scientific Sequencers
Kit Composition Provides all required reagents, including RNA to cDNA kit, cDNA to captured library kit, and bioinformatics SW
Bioinformatics Pipeline Stand-alone bioinformatics SW 'Celemics Virus Verifier' ( FASTQ to Visual Report )

Specification - Pathogen List

Human Adenovirus Coronavirus Parainfluenza Virus Respiratory Syncytial Virus
Human Adenovirus Type 1 (HAdV-C1) Coronavirus HKU1 Parainfluenza 1 (PIV 1) Respiratory Syncytial Virus A (RSV A)
Human Adenovirus Type 2 (HAdV-C2) Coronavirus NL63 Parainfluenza 2 (PIV 2) Respiratory Syncytial Virus B (RSV B)
Human Adenovirus Type 3 (HAdV-B3) Coronavirus 229E Parainfluenza 3 (PIV 3) Human Metapneumovirus
Human Adenovirus Type 4 (HAdV-E4) Coronavirus OC43 Parainfluenza 4 (PIV 4) A
Human Adenovirus Type 5 (HAdV-C5) SARS-CoV-2 Parainfluenza 4 (PIV 4) B
Human Adenovirus 7 (HAdV-B7)
Human Adenovirus 14 (HAdV-B14 Human Enterovirus Human Rhinovirus (A/B/C)
Human Adenovirus 21 (HAdV-B21) Influenza A EV-C104 Human Rhinovirus A
Influenza A-H7 Virus (Flu A-H7) EV-C105 Human Rhinovirus B
Bocavirus 1/2/3/4 (HBoV) Influenza A-H1 Virus (Flu A-H1) EV-C109 Human Rhinovirus C
Human Bocavirus 1 Influenza A-H3 Virus (Flu A-H3) EV-C117
Human Bocavirus 2 EV-C118
Human Bocavirus 3 Influenza B CV-A21
Human Bocavirus 4 Influenza B Virus (Flu B) EV-D68

Related Products

related-product

Stabilize RNA to double-stranded cDNA for unquestionable performance

related-product

Highly optimized, user- convenient NGS library preparation kit for all Celemics panels

Celemics Analysis Service

End-to-end complete Bioinformatics solution; Trust CAS with your BI analysis

Streptavidin Bead

Incomparable quality magnetic bead for simple, flexible, and reproducible purification

Resources

Technical Resources

[Product Overview] Comprehensive Respiratory Virus Panel

[Case Study] SARS-CoV-2 in hospital air as revealed by comprehensive

[Product Overview] Celemics Target Enrichment Panel Overview

[Catalogue] Celemics Products & Service Catalogue_All Products & Service

Safety Data Sheets

MSDS_Comprehensive Respiratory Virus Panel_Illumina

MSDS_Comprehensive Respiratory Virus Panel_Thermo Fisher

MSDS_Comprehensive Respiratory Virus Panel_MGI

References

Transboundary and Emerging Diseases

Genomic Epidemiology of African Swine Fever Virus Identified in Domestic Pig Farms in South Korea during 2019–2021

Kwon O-K, Kim D-W, Heo J-H, Kim J-Y, Nah J-J, Choi J-D, et al. Genomic epidemiology of African swine fever virus identified in domestic pig farms in South Korea during 2019–2021. Transbound Emerg Dis. 2024;2024:1–11.

 

10.1155/2024/9077791


View Detail >

Scientific Reports

Genomic epidemiology and evolutionary analysis during XBB.1.16-predominant periods of SARS-CoV-2 omicron variant in Bangkok, Thailand: December 2022–August 2023

Puenpa J, Chansaenroj J, Suwannakarn K, Poovorawan Y. Genomic epidemiology and evolutionary analysis during XBB.1.16-predominant periods of SARS-CoV-2 omicron variant in Bangkok, Thailand: December 2022–August 2023. Sci Rep. 2024;14(1).

 

10.1038/s41598-023-50856-0


View Detail >

Microbiology Resource Announcements

Genome characterization of a Korean isolate of porcine epidemic diarrhea virus

Kim D-M, Moon S-H, Kim S-C, Lee TG, Cho H-S, Tark D. Genome characterization of a Korean isolate of porcine epidemic diarrhea virus. Microbiol Resour Announc. 2024;13(1).

 

10.1128/mra.00118-23


View Detail >

Microbiology Spectrum

Canine respiratory coronavirus in Thailand undergoes mutation and evidences a potential putative parent for genetic recombination

Poonsin P, Wiwatvisawakorn V, Chansaenroj J, Poovorawan Y, Piewbang C, Techangamsuwan S. Canine respiratory coronavirus in Thailand undergoes mutation and evidences a potential putative parent for genetic recombination. Microbiol Spectr. 2023;11(5).

 

10.1128/spectrum.02268-23


View Detail >