NGS Pathogen Analysis Kit
Broad Pathogen Coverage · Streamlined Sample-to-Report Workflow · High Sensitivity in Complex Samples
Overview
Integrated NGS Kits and Bioinformatics for Pathogen Analysis and Surveillance
Celemics provides comprehensive pathogen NGS solutions utilizing both amplicon-based and hybridization-based enrichment technologies. These solutions enable reliable identification of viruses, bacteria, fungi, and parasites, even in samples with low pathogen concentrations or
high complexity. The entire workflow is supported through Celemics Kits, validated protocols, and automated bioinformatics pipeline, covering every step from sample preparation to the generation of the analysis report
Features & Benefits
Validated High Sensitivity
with Low-quality Field Specimens
Celemics’ pathogen panels have completed analytical and clinical validation using low-input and degraded field samples. High genome coverage was consistently achieved even in challenging samples with low pathogen concentrations, demonstrating reliable limit of detection (LOD) performance across diverse viral targets.
Superior Genome Coverage Even in Challenging and Low-quality Samples
(A) Exceptional Sensitivity across the Viral Load Spectrum
Amplicon-based panels delivered exceptional genome coverage even for challenging segmented viral genomes such as Influenza A and B, specifically in difficult-to-capture regions including HA (Segment 4) and NA (Segment 6).
(B) Suitable for detection of pathogens even in low-copy clinical samples
Hybridization-based panels reliably maintained high genome coverage (>90%) in hypervariable genomic regions and low-copy clinical samples, validated even at viral loads with Ct values above 32.
Exceptional Sensitivity Across the Viral Load Spectrum
Influenza A
Influenza B
Influenza A - NA Segment
Celemics
Company I
* 1.2 M reads / sample
A
Respiratory Syndrome Panel
Hemorrhagic Fever Syndrome Panel
B
High-Coverage Detection
of Single and Co-Infections
Celemics pathogen panels deliver consistent, high-sensitivity detection of viruses,
bacteria, and fungi—even in co-infection models and host-contaminated samples.
Validated across single, dual, and triple pathogen mixtures, the panels achieved over 90%
genome coverage in both clinical and environmental samples, ensuring accurate pathogen
Consistent High Genome Coverage in Single and Multiple Pathogen
(A) Multiple Pathogen Detection
Validated detection performance in samples containing single or multiple pathogens. Consistently achieved >90% genome coverage across diverse viral and bacterial pathogens in co-infection models.
(B) Coverage Performance of Celemics RSV Panel
Reliable detection across a broad range of clinically relevant respiratory pathogens. Demonstrated consistent >90% genome coverage across diverse viral and bacterial respiratory agents through repeated validation tests.
Multiple Pathogen (Co-Infection) of Fever Syndrome Panel
Single Pathogen - Viruses
Single Pathogen - Bacteria
2 pathogens
3 pathogens
A
RSV A
RSV B
* The resulting reads were downsampled to 0.6 million per sample for analysis
B
Tailored Enrichment Technologies
for Your Research: Amplicon or Hybridization
Celemics offers both amplicon- and hybridization-based target enrichment technologies,
allowing researchers to select the optimal method based on pathogen characteristics,
sample complexity, and analytical goals. Amplicon panels are ideal for rapid, cost-effective
detection of known targets in high-throughput workflows, while hybridization panels
provide broad coverage, mutation tolerance, and reliable performance even in host-rich or
low-quality samples.
Comparison of Amplicon-based vs.
Hybridization-based Enrichment
This clear comparison helps researchers easily
determine the most suitable enrichment technology
for their specific applications.
| Amplicon-based | Hybridization-based | |
|---|---|---|
| Main Feature | Rapid amplification of known target regions |
Variant detection, high-throughput known-pathogen screening |
| Key Applications | Variant detection, high-throughput known-pathogen screening |
Identification of novel pathogens, complex or diverse microbial samples |
| Sensitivity | Very high (ideal for specific targets at low abundance) |
High (especially robust in complex, low-copy samples) |
| Mutation Tolerance | Limited (sensitive to mutations at primer-binding sites) |
Excellent (primer-independent; robust against sequence variation) |
| Panel Size & Flexibility | Limited (restricted to pre-designed primer regions) |
Highly flexible (easily scalable to large target regions) |
| Workflow Speed | Faster (~1 day or less) |
Moderate (~1–2 days) |
| Cost-efficiency | High for known, targeted applications | Efficient for large, complex target panels |
Easily Accessible
Bioinformatics Analysis Platform
Celemics provides an analysis solution that generates visualized reports, enabling users to
easily assess sequencing QC and detect pathogens and their variants from FASTQ files —
starting from data upload to report generation with just a few clicks.
Data
Upload
Automated
Analysis
Visualized
Report
Customize for Your Research Needs
Our flexible panel design services allow you to add genes, regions, or entire organisms to
your target list—whether for zoonotic tracking, environmental surveillance, or vaccine
development. We also support spike-in of mitochondrial or intronic regions upon request.
Workflow
Simple and Fast Workflow
without the Need of Special Instruments
Celemics’ kits provide streamlined protocols with minimal hands-on time and do not
require any specialized instruments for library preparation or enrichment. This enables
easy adoption across laboratories with varying levels of equipment and automation.
1.Sample Input
(DNA/RNA)
3.Sequencing
Compatible with All
Sequencing Platforms
Data Upload &
Automated Bioinformatics Analysis
→ Visualized Report
& Consensus Genome Output
4.Analysis
2-1.Amplicon-based
2-2.Hybridization-based
Target
Amplification
Target
Enrichment
Library
Preparation
Library
Preparation
1.Sample Input
(DNA/RNA)
Hybridization-based
Target
Enrichment
Library
Preparation
Amplicon-based
Library
Preparation
Target
Amplification
Compatible with All
Sequencing Platforms
3.Sequencing
Data Upload &
Automated Bioinformatics Analysis
→ Visualized Report
& Consensus Genome Output
4.Analysis
Specification
Amplicon-based Pathogen Enrichment Kits (Ready-to-use Panel)
| Pathogen | Influenza A/B Virus | Respiratory syncytial Virus A/B | Human Metapnuemovirus A/B |
|---|---|---|---|
| Target Region | Whole genome | Whole genome (>98%) | Whole genome (>98%) |
| Enrichment Method | Multiplex PCR | ||
| Hands-on Time | 2.5 hr (Assay Time 8 hrs) | ||
| Sample Type | Sputum, nasopharyngeal and oropharyngeal swabs and aspirate, tissue samples, and other methods for viral RNA sampling. | ||
| Bioinformatics Pipeline |
FASTQ to VCF Consensus genome sequence Analysis report |
||
Hybridization-based Pathogen Enrichment Kits (Ready-to-use Panel)
Comprehensive Respiratory Virus Panel
| Target Viruses* | 9 types / 39 virus strains, including SARS-CoV-2 |
|---|---|
| Target Size | 706 Kb |
| Mutation Analysis | Variant detection, Viral mutation (SNV, Indel) from generated Whole Genome Sequence |
| Sample Type | URT, NP/OP, etc. |
| Platform | All Illumina and Thermo Fisher Scientific Sequencers |
| Kit Composition | Provides all required reagents, including RNA to cDNA kit, cDNA to captured library kit, and bioinformatics SW |
| Bioinformatics Pipeline | Stand-alone bioinformatics SW 'Celemics Virus Verifier' (FASTQ to Visual Report) |
African Swine Fever Virus Panel
| Target Viruses* | ASFV 26 strains |
|---|---|
| Target Size | 192 kb |
| Mutation Type | Virus detection, Virus genome assembly |
| Sample Type (amount) | Swine Blood (> 50 ng of fragmented DNA) |
| Platform | All sequencers from Illumina, Thermo Fisher, MGI, PacBio, and Oxford Nanopore |
| Bioinformatics Support | Celemics Virus Verifier (Detection report) |
Related Products
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Highly optimized, user- convenient NGS library preparation kit for all Celemics panels
CeleMag Clean-up Bead
Incomparable quality magnetic bead for simple, flexible, and reproducible purification
Comprehensive Respiratory
Respiratory Virus Comprehensive analysis of 9 different virus types, 39 strains of clinically significant respiratory viruses
African Swine Fever Virus Panel
Virus Accurate identification of various ASFV strains in a single NGS reaction with species-specific blocker
Highly optimized, user- convenient NGS library preparation kit for all Celemics panels
Incomparable quality magnetic bead for simple, flexible, and reproducible purification
Respiratory Virus Comprehensive analysis of 9 different virus types, 39 strains of clinically significant respiratory viruses
Virus Accurate identification of various ASFV strains in a single NGS reaction with species-specific blocker
Resources
Technical Resources