Mitochondrial DNA Panel
High uniformity and complete coverage of human mitochondrial genome
Overview
Specifically Designed for Small Target Region-based Whole mtDNA Genome Analysis
Celemics mitochondrial DNA sequencing panel enables the same high level of target capture efficiency regardless of small target sizes even with a stand-alone panel
Celemics has specifically designed the hybridization probes and adjusted the concentration of the panel for each respective use with our own proprietary rebalancing technologies to provide complete, consistent coverage of the whole mtDNA genome while taking into consideration small target regions. This enables the same high level of target capture efficiency regardless of small target sizes even with a stand-alone panel.
High-fidelity Sequencing
Along with our proprietary assay development and optimization technologies, we ensure to present maximum capture efficiency in custom panels without affecting target specificity. You will experience our market-leading coverage and uniformity across the entire human mitochondrial genome.
IGV Example of Celemics mtDNA Sequencing Panel
Celemics mtDNA Sequencing Panel shows over 99% with high uniformity
Celemics’ mtDNA sequencing can be performed in two different ways, depending on how the library is prepared. The hybridization-based panel is performed by using specifically designed capture probes. Our own proprietary rebalancing technologies provide sequencing results with complete and consistent coverage of the mtDNA whole genome.
| NGS Sequencing Amount | On-target Base Ratio |
Mean Depth | Coverage | ||
|---|---|---|---|---|---|
| 10x | 50x | 100x | |||
| 10Mb | 97.93% | 493x | 99.98% | 99.91% | 99.87% |
Flexible Customized Panel
The panel can conveniently added on to other Celemics’ ready-to-use target enrichment panels, such as G-Mendeliome panels for further mtDNA-derived rare disease discoveries, or simply develop a full set of customized panel to include mitochondrial DNA analysis.
Specification
| Covered region | Whole mitochondrial genome |
|---|---|
| Target size | 16.6 kb |
| Mutation type | SNV, Indel |
| Sample type (amount) | Blood (> 50 ng of fragmented DNA) |
| Platform | All sequencers from Illumina, Thermo Fisher, MGI, PacBio, and Oxford Nanopore |
| Bioinformatics Support | ① Primary Analysis: FASTQ to annotated VCF ② Secondary Analysis: Large InDel |
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Incomparable quality magnetic bead for simple, flexible, and reproducible purification
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Resources
Technical Resources
Safety Data Sheets