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CeleMag™ Clean-up Bead
Innovative High Purification Efficiency Magnetic Bead for NGS Workflow
Overview
CeleMag™ Clean-up Bead
CeleMag™ Clean-up Bead utilizes unique magnetic bead-based chemistry to enable a simple, flexible, and easily reproducible workflow for the purification and size selection of nucleic acids required for your NGS procedure.
Not only it is highly optimized to be used with all Celemics’ target enrichment kits, but CeleMag™ Clean-up Bead will also demonstrate strong compatibility with NGS kits from other providers due to Celemics’ exclusive technology to stabilize the buffer and bead conditions.
Features & Benefits
Superior Recovery Ratio
Celemics’ exclusive magnetic bead and buffer conditioning technologies ensure
CeleMag™ Clean-up Bead to maximize the DNA recovery after purification with easy-to-follow protocols.
Comparison of DNA recovery yield between Celemics' CeleMag™ Clean-up Bead and Competitor's Bead AP
- 500 ng of DNA was purified using bead from both parties. Average DNA recovery yield of CeleMag™ Clean-up Bead was higher(86.5%; 432.6 ng) than those of purified with Bead AP(75.8%; 378.9 ng)
| Average amount of DNA recovered(Input 500 ng) | |
|---|---|
| CELEMICS | 432.6 ng |
| Bead AP | 378.9 ng |
Robust Reproducibility
CeleMag™ Clean-up Bead provides superior reproducibility compared to other competitor products, ensuring robustness and consistency for purification while maximizing the yield.
Comparison of total DNA recovery rate between Celemics' CeleMag™ Clean-up Bead and Competitor's Bead AP
- 500 ng of DNA was purified using bead from both parties. Of the replicated 5 samples, the overall average of recovered rate of CeleMag™ Clean-up Bead was higher(average of 86.5%) than those of purified with Bead AP(average 75.8%)
| Input 500 ng | DNA recovered(ng) | |
|---|---|---|
| CELEMICS | Bead AP | |
| Replicate 1 | 473.6 | 387.2 |
| Replicate 2 | 416.0 | 368.0 |
| Replicate 3 | 438.4 | 364.8 |
| Replicate 4 | 416.0 | 377.6 |
| Replicate 5 | 419.2 | 396.8 |
| Average (ng) | 432.6 | 378.9 |
Size Selection Capacity
Celemics’ exceptional reagent optimization technology for clean-up bead will allow flexible yet efficacious isolation of desired fragments depending on sample-to-bead ratio options. CeleMag™ Clean-up Bead’s efficient and effective selection and purification capacity will deliver the desired nucleic acids for your NGS workflow.
Fragmented DNA size selection with respect to changes in amount of bead
- The amount of sample loaded was 50 μL and was analyzed on Agilent’s TapeStation® 4200. The result showed gradual increase in selected band(marked with orange arrow) as the sample to bead ratio decreased.
| Experiment Condition | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Sample to Bead Ratio | 1.8X | 1.5X | 1.2X | 1.1X | 1.0X | 0.9X | 0.8X | 0.7X | 0.6X | 0.5X |
Specification
| Product | Product Unit |
|---|---|
| CeleMag™ Cleand-up Bead | 5 mL |
| 50 mL | |
| 500 mL |
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