Overview
End-to-end Customized Target Enrichment Panel
Celemics target enrichment panel employs hybridization-based capture technology to enable targeted sequencing, facilitating the analysis of specific regional sequences of entire genomes. It accurately analyzes various types of mutations, including single nucleotide variants (SNVs), insertions/deletions (InDels), copy number variations (CNVs), and rearrangements.
Celemics’ target enrichment panel utilizes our proprietary probe design, rebalancing, blocker, and assay optimization technologies to efficiently analyze not only hard-to-capture areas such as GC-rich and homologous regions, but also tiny amounts of damaged DNA or RNA originated from circulating tumor cells or FFPE samples.
Celemics has successfully developed and delivered over 1,000 custom panels. Our target enrichment approach specifically isolates genomic regions of interest, leading to enhanced sensitivity in detecting genetic mutations through increased coverage with cost-effectiveness.
Features & Benefits
Industry-leading On-Target Ratio and Uniformity of Hybridization-based Target Enrichment
On-target ratio, uniformity, and great capture performance in GC-rich and homologous regions, even with difficult and small sample amounts, are all important to researchers and clinicians.
Celemics has developed proprietary technologies for probe design, synthesis, blockers, and assay optimization, resulting in best-in-class capture performance.
With our industry-leading performance, customers can increase the sensitivity of the tests and reduce sequencing costs.
Comparison Result
Celemics kit shows much uniform target capture performance, thus enabling high sensitivity and cost reduction
Celemics
Company A
This comparison study was performed with same target region, same data amount, and same analysis method.
Exceptional Capture Performance, even in GC-rich and Homologous Regions
GC-rich and homologous regions are often challenging to capture, and some vendors deliberately exclude these regions, making it difficult to analyze important mutations. However, Celemics uses proprietary technology to ensure excellent capture capabilities, even in these areas. We provide custom target region analysis results and discuss all the details with our customers to ensure they don’t miss any important information embedded in these regions.
Comparison Result - GC/AT-rich regions
Celemics panels show superior uniformity across both GC-rich and AT-rich regions compared to Competitor products
Robust Performance of Assessing DNA and RNA Across Various Specimen Quality
Obtaining reliable NGS data from DNA and RNA extracted from FFPE, ctDNA, and specimens with low viral loads can be challenging. However, Celemics’ assay optimization technology enables our customers to analyze such specimens with market-leading performance. Our NGS panel is compatible with poor-quality and low-quantity specimens such as FFPE, solid tumors, ctDNA (liquid biopsy), and more.
Robust performance with low-yield, poor quality FFPE sample
Panel shows robust performance regardless of sample types; even with poor quality and low-input FFPE sample
Experimental condition
- Sample Type: Highly degraded FFPE samples
- DNA input: 10 / 50 ng
Experimental condition
- Sample Type: Clinical samples
- DNA input: 50 ng
Simple Rapid Workflow
Target enrichment workflows are often considered complex and time-consuming. However, Celemics has developed a unique and streamlined workflow that reduces errors, hands-on time, and overall processing time. Our simplified enzymatic library preparation with fast hybridization workflow enables us to reduce both time and internal costs, while maintaining excellent performance.
The conventional NGS workflow typically requires heavy instruments in the process, such as size and amount characterization for library normalization and a vacuum concentrator for hybridization mix concentration. However, Celemics provides a new workflow that eliminates the need for these heavy instruments. Our unique workflow also allows complete walkaway automation, eliminating the need for multiple manual steps that are required with conventional kits that use heavy instruments. With Celemics’ workflow, samples do not need to be taken out from the automation machine until the end of the process, which improves efficiency and reduces errors.
Simple process and workflow of Celemics customized NGS panel
We developed proprietary technologies to provide most affordable, cost-reducing product in the market: Simple enzymatic fragmentation kits with fast hybridization technology with user-friendly Click-to-Report bioinformatics SW
Target
Gene
Selection
Interactive discussion
with customer prior
to panel design
Elaborate
Design of the
Capture Probe
Integration of
Celemics proprietary
technology for the
best panel performance
Synthesis of
the Capture
Probe
Advanced technology for probe synthesis and reagent optimization
In-house
Performance
Test
Detailed QC results
encompassing, Web-lab experiments, NGS runs, and BI analysis provided to customer
Probe
Rebalancing
Able to increase depth and coverage of a specific area by request
Kit
Production
Target
Gene
Selection
Interactive discussion
with customer prior
to panel design
Elaborate
Design of the
Capture Probe
Integration of
Celemics proprietary
technology for the
best panel performance
Synthesis of the
Capture
Probe
Advanced technology for probe synthesis and reagent optimization
In-hose
Performance
Test
Detailed QC results
encompassing, Web-lab experiments, NGS runs, and BI analysis provided to customer
Probe
Rebalancing
Able to increase depth and coverage of a specific area by request
Kit
Production
Target
Gene
Selection
Interactive discussion
with customer prior
to panel design
Elaborate
Design of the
Capture Probe
Integration of
Celemics proprietary
technology for the
best panel performance
Synthesis of the Capture
Probe
Advanced technology for probe synthesis and reagent optimization
In-hose
Performance
Test
Detailed QC results
encompassing, Web-lab experiments, NGS runs, and BI analysis provided to customer
Probe
Rebalancing
Able to increase depth and coverage of a specific area by request
Kit
Production
Interactive discussion
with customer prior to panel design
Integration of
Celemics proprietary
technology for the best panel performance
Advanced technology for probe synthesis and reagent optimization
Detailed QC results
encompassing, Web-lab experiments, NGS runs, and BI analysis provided to customer
Able to increase depth and coverage of a specific area by request
Real QC of All Customized Panel
Current in-silico methods make it difficult to accurately predict DNA capture levels, which can only be determined through actual demo experiments. It’s important for customers to know their panel’s performance before using it in their laboratory. That’s why all of our customized panels undergo performance validation experiments using reference DNA, and we send the test results to our customers before they begin using them in their laboratory. This allows customer to verify that all the variants of interest are analyzable, to detect any false negatives, and to calculate the number of samples that can be sequenced in a single NGS run.
Easy “Click-to-Report” Bioinformatics Service
We offer the Celemics Analysis Service (CAS) to assist customers in need of bioinformatics support. The CAS system allows for easy data transmission via a single-click and automated upload process. Our team of bioinformatics experts provide complete support, eliminating the need for third-party bioinformaticians. CAS also offers real-time troubleshooting at every stage of analysis, and can be customized according to the specific needs of the client.
In addition, we provide comprehensive clinical interpretation services through a CAP-accredited partner. This service combines bioinformatics algorithms, public data from external sources and knowledge databases, visualization interfaces, and reporting capabilities to deliver a detailed report that includes pathogenicity and drug-associated information.
Provision of White-labeled Customized Product for Supporting Customer’s Business Expansion
We offer white-labeled customized products to support our customers’ business expansion. This means that we can produce customized panels with the customer’s branding and labeling, allowing them to market and sell the product under their own brand. This service provides a cost-effective way for our customers to expand their business while maintaining their brand identity. By partnering with Celemics, customers can leverage our expertise in custom panel development and manufacturing, while also benefiting from our fast turnaround times and consistent high-quality products.
Other Features
For Repeated Customized Panel Orders: Highly Uniform Lot-to-lot Quality and Fast Delivery
Highly uniform lot-to-lot quality and fast kit delivery for repeated orders made possible with our 2-step probe manufacturing technology. We ensure every lot of custom panel kits has the same high quality and consistency providing customers with reliable and reproducible results for all orders. Additionally, we offer industry-leading fast delivery for repeated custom panel orders worldwide for fast and efficient sequencing.
Gene Add-on Service and Various Reaction Unit Options
We offer customers to add new target genes to their existing panels without having to purchase an entirely new panel.
In addition, customers can select from various reaction unit options, allowing efficient, flexible and cost-saving NGS solutions
Wide Compatibility with NGS Instruments and Instrument-specific Optimization
Our panels are compatible with various sequencing platforms, such as Illumina, Thermo Fisher, MGI, and Pacific Bioscience.
All Celemics panels allow flexible integration, optimized with different blockers and assys for each instrument to ensure best possible performance.
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