CancerMaster Panel

Comprehensive panel for somatic cancer and immuno-oncology markers

Overview

CancerMaster 패널

CancerMaster 패널은 유전자 내 발생하는 모든 유전 변이에 더하여 면역 치료 반응에 중요한 것으로 알려진 마커 (Immuno-oncology 마커)들을 정밀하게 분석할 수 있는 패널입니다. 특히 CNV 분석에서는 암세포 비율에 따라 다른 Cut-off를 적용한 분석을 진행하며 Epstein-Barr Virus (EBV) 및 Human Papillomaviruses (HPV) 분석 또한 진행 가능해 암 연관 유전자들의 종합적인 분석이 가능합니다.

CancerMaster
Features & Benefits

암 연관 유전자에 대한 포괄적인 정보 제공

CancerMaster는 다양한 종류의 암종에 연관된 유전자에 대한 종합적인 분석 결과를 제공하기 위해 개발된 패널입니다. Somatic variants는 물론 TMB, MSI 분석을 위한 Immuno-oncology 마커 및 EBV, HPV와 같은 암 연관 바이러스 분석까지 폭넓은 타겟 범위를 모두 커버할 수 있도록 설계되었습니다

ANALYSIS OF EBV & HPV

EBV (Epstein-Barr Virus) HPV (Human Papillomavirus)
- Related disease - Lymphoma
- Genes - EBV type1 (EBNA-2)
- Related disease - Cervical cancer
- Genes - HPV L1 gene
 (Analysis of a total of 24 types is possible)
Validation for detection of EBV type1 (EBNA - 2)
in control specimens
Analysis of the following 11 types of HPV types was completed using clinical specimens

임상 수준에서 검증된 패널 성능

암 연구는 패널 성능은 통한 일관된 결과를 제공할 수 있어야 함은 물론 재현성이 확보되어야 합니다. 셀레믹스의 CancerMaster 패널은 다양한 표준물질 및 일반적인 샘플은 물론 임상 수준의 검체에 대해서도 성능 평가를 완료한 패널입니다.

Variants of CacerMaster (764 Samples)

Variants of CancerMaster (764 Samples)

Variants of CacerMaster (764 Samples)

Specification

*Gene Add-On Service: Genes can be added by customer’s request.
Gene count* 524 genes
Covered region Whole CDS, Custom regions of oncogenes, immune response genes, and EBV & HPV viruses
Target size 2.5 Mb
Mutation type SNV, Indel, CNV, Rearrangement, TMB, MSI, EBV, HPV
Sample type FFPE, Fresh frozen tissue (> 50 ng of fragmented DNA)
Platform All sequencers from Illumina, Thermo Fisher, MGI, PacBio, and Oxford Nanopore
Bioinformatics Support ① Primary Analysis: FASTQ to annotated VCF
② Secondary Analysis: CNV, Large InDel, MSI, TMB
③ Tertiary Analysis: Clinical interpretation

Specification - Gene List

CancerMaster Panel

  • 524 genes | Gene count
  • 2.5 Mb | Target Size
  • Whole CDS, Custom regions of oncogenes, Immune response genes, and EBV & HPV viruses | Target Region
ABL1 ABL2 ACVR1 ACVR1B ADAM29 ADGRA2 AKT1 AKT2 AKT3 ALK ALOX12B ALOX15B AMER1 APC APCDD1 APEX1 APOB APOBEC1 APOBEC3
A
APOBEC3
B
AR ARAF ARFRP1 ARID1A ARID1B ARID2 ASXL1 ATM ATP11B ATR ATRX AURKA AURKB AXIN1 AXL B2M B3GAT1 BACH1 BAP1 BARD1
BCL2 BCL2A1 BCL2L1 BCL2L2 BCL6 BCL9 BCOR BCORL1 BCR BIRC2 BIRC3 BLM BRAF BRCA1 BRCA2 BRD2 BRD3 BRD4 BRIP1 BTG1
BTK BTLA CARD11 CASP5 CASP8 CBFB CBL CCDC150 CCDC168 CCDC43 CCL2 CCL4 CCND1 CCND2 CCND3 CCNE1 CD27 CD274 CD276 CD28
CD3D CD3E CD3G CD4 CD40 CD44 CD79A CD79B CD8A CDC42 CDC73 CDH1 CDH2 CDH20 CDH5 CDK12 CDK4 CDK6 CDK8 CDKN1A
CDKN1B CDKN2A CDKN2B CDKN2C CDX2 CEBPA CHD1 CHD2 CHD4 CHEK1 CHEK2 CHUK CIC CRBN CREBBP CRKL CRLF2 CSF1R CSF2 CSF2RA
CSF2RB CSNK2A1 CTCF CTLA4 CTNNA1 CTNNB1 CUL3 CUL4A CUL4B CXCL10 CXCL11 CXCL9 CXCR3 CYLD CYP17A1 DAXX DCUN1D1 DDR2 DICER1 DIS3
DNMT1 DNMT3A DOCK2 DOT1L EGFR ELMO1 EML4 EMSY EP300 EPHA3 EPHA5 EPHA6 EPHA7 EPHB1 EPHB4 EPHB6 ERBB2 ERBB3 ERBB4 ERCC1
ERCC2 ERG ERRFI1 ESR1 ETV1 ETV4 ETV5 ETV6 EWSR1 EYA2 EZH2 FAM46C FANCA FANCC FANCD2 FANCE FANCF FANCG FANCI FANCL
FANCM FAS FAT1 FAT3 FBXW7 FGF1 FGF10 FGF12 FGF14 FGF19 FGF2 FGF23 FGF3 FGF4 FGF6 FGF7 FGFR1 FGFR2 FGFR3 FGFR4
FH FLCN FLT1 FLT3 FLT4 FOXA1 FOXL2 FOXO3 FOXP1 FOXP3 FRS2 FUBP1 GABRA6 GAS6 GATA1 GATA2 GATA3 GATA4 GATA6 GID4
GLI1 GNA11 GNA13 GNAQ GNAS GRIN2A GRM3 GSK3B GUCY1A2 GZMA GZMB GZMH H3F3A HGF HIST1H3B HLA-A HLA-B HLA-C HLA-DRA HLA-E
HLA-F HLA-G HNF1A HOXA3 HRAS HSD3B1 HSP90AA1 IDH1 IDH2 IDO1 IDO2 IFITM1 IFITM3 IFNA1 IFNB1 IFNG IGF1 IGF1R IGF2 IGF2R
IKBKE IKZF1 IL12A IL12B IL2 IL23A IL6 IL7R INHBA INPP4B INSR IRF2 IRF4 IRS2 ITGAE ITK JAK1 JAK2 JAK3 JUN
KAT6A KDM5A KDM5C KDM6A KDR KEAP1 KEL KIT KLF4 KLHL6 KMT2A KMT2B KMT2C KNSTRN KRAS LAG3 LMO1 LRP1B LRP6 LTK
LYN LZTR1 MAGI2 MAGOH MAML1 MAP2K1 MAP2K2 MAP2K4 MAP3K1 MAP3K13 MAPK1 MAX MCL1 MDM2 MDM4 MED12 MEF2B MEN1 MET MITF
MLH1 MPL MRE11 MSH2 MSH6 MTOR MUTYH MYB MYC MYCL MYCN MYD88 MYO18A NCOA3 NCOR1 NF1 NF2 NFE2L2 NFKBIA NKX2-1
NKX2-8 NKX3-1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 NPM1 NRAS NSD1 NSD3 NTRK1 NTRK2 NTRK3 NUP93 NUTM1 PAK3 PAK5 PALB2 PARK2 PARP1
PARP2 PARP3 PARP4 PAX5 PBRM1 PDCD1 PDCD1LG2 PDGFRA PDGFRB PDK1 PGR PHF6 PHLPP2 PIK3C2B PIK3C3 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2
PKHD1 PLCG1 PLCG2 PMS2 PNP PNRC1 POLD1 POLE PPARG PPP2R1A PRDM1 PREX2 PRF1 PRKAR1A PRKCI PRKDC PRPF40B PRSS8 PTCH1 PTCH2
PTEN PTK2 PTPN11 PTPRC PTPRD QKI RAB35 RAC1 RAC2 RAD17 RAD50 RAD51 RAD51B RAD51C RAD51D RAD52 RAD54L RAF1 RANBP2 RARA
RB1 RBM10 REL RET RHEB RHOA RHOB RICTOR RNF43 ROBO1 ROBO2 ROS1 RPA1 RPS6KB1 RPTOR RUNX1 RUNX1T1 RUNX3 SDHA SDHB
SDHC SDHD SEMA3A SEMA3E SET SETBP1 SETD2 SF3A1 SF3B1 SH2B3 SKP2 SLIT2 SMAD2 SMAD3 SMAD4 SMARCA1 SMARCA4 SMARCB1 SMARCD1 SMO
SNCAIP SOCS1 SOX10 SOX2 SOX9 SPEN SPOP SPTA1 SRC SRSF1 SRSF2 SRSF7 STAG2 STAT3 STAT4 STK11 SUFU SYK TACC3 TAF1
TBX22 TBX3 TERC TERT TET2 TGFBR2 TIAF1 TIGIT TIPARP TMPRSS2 TNF TNFAIP3 TNFRSF14 TNFRSF18 TNFRSF4 TNFSF13B TNKS TNKS2 TOP1 TOP2A
TP53 TRAF7 TRRAP TSC1 TSC2 TSHR U2AF1 U2AF2 USP9X VEGFA VHL VSIR VTCN1 WISP3 WNT1 WT1 WWP1 XBP1 XPO1 XRCC3
ZBTB2 ZNF217 ZNF703 ZRSR2

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Resources

Technical Resources

[Product Overview] CancerMaster Panel

[Product Overview] Celemics Target Enrichment Panel Overview

[Catalogue] Celemics Products & Service Catalogue_All Products & Service

Safety Data Sheets

MSDS_CancerMaster Panel_Illumina_Enzymeplus

MSDS_CancerMaster Panel_Illumina

MSDS_CancerMaster Panel_Thermo Fisher

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References

Epigenomics

Identification of tissue of origin in cancer of unknown primary using a targeted bisulfite sequencing panel

Bae JM, Ahn JY, Lee H, Jang H, Han H, Jeong J, et al. Identification of tissue of origin in cancer of unknown primary using a targeted bisulfite sequencing panel. Epigenomics. 2022 May;14(10):615–28.

 

10.2217/epi-2021-0477


View Detail >

Investig Clin Urol

Germline pathogenic variants in unselected Korean men with prostate cancer

So MK, Ahn HK, Huh J, Kim KH. Germline pathogenic variants in unselected Korean men with prostate cancer. Investig Clin Urol. 2022 May;63(3):294–300.

 

DOI 10.4111/icu.20220044


View Detail >

Scientific Reports

Feasibility of targeted cascade genetic testing in the family members of BRCA1/2 gene pathogenic variant/likely pathogenic variant carriers

Lee J, Ham JY, Park HY, Jung JH, Kim WW, Kang B, et al. Feasibility of targeted cascade genetic testing in the family members of BRCA1/2 gene pathogenic variant/likely pathogenic variant carriers. Sci Rep. 2022 Feb 3;12(1):1842.

 

DOI 10.1038/s41598-022-05931-3


View Detail >

BMC Medical Genomics

A novel bi-alleleic DDX41 mutations in B-cell lymphoblastic leukemia: case report

Shin WY, Yoon SY, Park R, Kim JA, Song HH, Bang HI, et al. A novel bi-alleleic DDX41 mutations in B-cell lymphoblastic leukemia: case report. BMC Med Genomics. 2022 Mar 4;15(1):46.

 

DOI 10.1186/s12920-022-01191-2


View Detail >